Describe inversions and translocations in the structure of chromosomes
INVERSIONS:
The inversion is
a type of chromosomal aberration in which a segment chromosome is turned around
180° and inserted into the chromosome. An inversion does not involve a loss of
genetic information but simply rearranges the linear gene sequence. An
inversion involves two breaks along the length of the chromosome prior to the
reinsertion of the inverted segment.
In those cases
where the centromere is not the part of the rearranged chromosome segment, the
inversion is said to be paracentric on other other hadn if the centrosome is a
part o the inverted segment, the inversion is known as Pericentric.
The organism
with one inverted chromosome and one non-inverted homologue present, are called
inversion heterozygotes.
Pairing between
such chromosome is not possible until they form an inversion loop. If crossing
over does not occur within the inverted segment of the inversion heterozygote,
the homologues will segregate normally. When crossing over occurs within the
inversion loop, abnormal chromatids are produced. A single cross over produces
two parental chromatids and two recombinant chromotids. In case of a
paracentric inversion one recombinant is Dicentric i.e. having two centrosome
and one recombinant is a centric i.e. lacking a centromere. Both contain
duplications and deletions of chromosome segments as well. During avaphase, an
acentric chromatid mones roudomly to one pole or the other or may be lost,
while a decentric chromatid is pulled in two directions.
This polarized
movements produces Dicentric Briodges. A deventric chewmated break at some
point so that part of the chromatid goes into newxt gamete and other part into
another gamete during the reduction division. In this way gametes which contain
other recombinant chromatid are deficient in genetic material when such a
gamete participates in fertilization the zygote most often develops abnormally.
During
pericentric inversion each tetrad yield two parental chromatids containing
complete set of genes and the recompinant chromatids have duplications and
deletions as they are diresctly involved inc crossing over. No acentric or
dicentric chromatids are produced. Gametes receiving these chromatids also
produce inviable embryos.
The inversion
results in new positioning of genes relative to other genes. If the expression
of a gene is altered as a result of its relocation, a change in phemotype may
result. Such a change is called position effect. In Drosophhilla females,
heterozygous for sex linked recesive mutation with eye (W+/W/, X
chromosome bearing the wild tupe allele (w) amy be inverted and the while locus
moves to a point adjacent to centro metric heterochromatin. If the inversion is
not present the heterozygous female ahs wild type red eye because the white
allele is recessive. Females with X chromosome inversion have eyes that are
mottled or variegated having red and white patches. Relation of W+
allele next to a heterochromatin area seems to cause a loss of complete
dominance over the recessive allele. Other genes located on X chromosome will
also behave in the same manner of shifted to some other place.
Genetic consequences of Inversion:
The process of
inversion maintains a set of alleles at a series of adjacent loco provided they
are contained within inversion. Because the recovery of cross over products is
suppressed in inversion heterozygotes, a particular gene sequence is preserved
intact in the viable gametes. If this gene order provides a survival advantage
to organism having it, the inversion is beneficial from evolutionary point of
view. For example if the set of alleles AB, DeF is more adaptive than the sets
AbcDEF or abcdEF, the favourable set will not be disturbed by the crossing over
if it is maintained within a heterozygous inversion.
TRANSLOCATIONS:
The transfer of
a section of one chromosome to a non homolofue is called tranlocation. In
Drosophilla, translocation was first recognised gentetically by the unusual
behaviour of second chromosome gene known as pale, which had the phemotypic
effect of diluting certain eye colours. Although pale was lethal in homozygous
conditions. Bridges found that its lethality and phenotypic effect could be
suppressed by the presence of another gene present on third chromosome which is
also lethal when homozygous. The lethality of the latter, in turn, was
suppressed by the presence of the former, linkave analysis soon sowed that the
pale effect was caused by deficiency for a small section of genes on the tip of
second chromosome which had linked to third chromosome between genes ebony and
rough. In other words deficiency and translocation has transferred a gene from
chromosome 2nd to 3rd.
At present a
variety of translocation are known among which following are most common.
(1) Simple translocation: They are produced
by single break in chromosome and transfer of a broken piece of this chromosome
directly into the end of another.
(2) Shifts or Intercalary Translocation:
They are more common and are produced by involving three breaks so that two
break section of one chromosome is inserted within the break produced in non
homologous chromosome.
(3) Reciprocal Translocation: These are
interchanges which occur when single breaks into two non homologous chromosomes
produce an exchange of chromosome sections between them.
GENETICS
CONSEQUENCES OF TRANSLOCATIONS:
(1) Process of translocation provides of one
the proof that genes are present on chromosomes.
(2) Translocation has also helped us to
understand the position effect i.e. when a chromosome rearrange ment involves
no change in the amount of genetic material but only in the order of genes, the
term position effect is used to describe any associated phenotypic alteration.
(3) Translocation sometimes is the cause of
sterility.
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