Short notes on Biochemistry of Hormones, Hypophysis,Pancreatic hormones and Adrenal glands
Biochemistry of Hormones or Chemical
nature of hormones:
Most hormones
are proteins (Polypeptides) derivates of amino acids (amines) or steroids. A
few are fatty acid derivates e.g. most invertebrate neurosecretary cells
produce polypeptides called neuropeptides. Hormones that the vertebrate
pancreas secretes are proteins; those that the thyroid gland secretes are
amines. The ovaries, testes and cortex of adrenal glands secrete steroids. Hormones
are effective in small amount. Only few molecules of hormone may be enough to
produce a dramatic response in a target cell. In target cell hormones help to control
biochemical reactions in three ways: (i) A hormone can increase the rate at
which other substances enter or leave the cell. (ii) It can stimulate a target
cell to synthesize enzymes, proteins or other substances. (iii) It can prompt a
target cell to activate or suppress existing cellular enzymes. Hormones are not
changed by reaction they regulate.
Lobes of pituitary glands (Hypophysis):
Pituitary gland
has two lobes, the anterior lobe (adenohypophysis) and posterior lobe
(neurohypophysis). Two lobes differ in several ways (i) Adenohypophysis is
larger than neurohypohysis (ii) Secretary cells called pituicytes are in
adenohypophysis but not in neurohypophysis (iii) Neurohypophysis has greater
supply of nerve endings. Pituicytes produce and secrete hormones directly from
adenohypophysis whereas neurohypophysis obtains it hormones from neurosecretory
cells in hypothalamus, storing and releasing then when they are needed. These
modified hypothalamic nerve cells project their axons down a stalk of nerve
cells and blood vessels called infundibulum into pituitary gland directly
linking the nervous and endocrine system.
Pancreatic hormones:
Pancreas is an
elongated fleshy organ posterior to stomach, endocrine portion of which makes
up only about 1% of the gland. This portion synthesizes, stores and secretes
hormones from clusters of cells called pancreatic islets of langerhans which
are many in number scattered throughout the gland. Each islet has four groups
of cells called alpha (α), beta (β), delta (δ), and F cells. Alpha cells
produce hormone glucagons and beta cells produce insulin. Delta cells secrete
somatostatin. The hypothalamic growth hormone inhibiting factor that also
inhibits glucagons and insulin secretion. F cells secrete pancreatic
polypeptide into blood stream after a meal and inhibits somatostain secretion,
gall bladder contraction and secretion of pancreatic digestive enzymes, when
glucose concentration in blood is high such as after a meal, beta cells secrete
insulin which promotes uptake of glucose by body cells including liver cells,
where excess glucose can be converted to glycogen.
Adrenal glands:
In mammals two
adrenal glands rest on top of the kidney. Each gland consists of inner portion
medulla and outer cortex.
Adrenal cortex: It
secretes three steroid hormones: cortisol, aldosterone and sex hormones
(anderogens, estrogens). The cotrisal helps to regulate over all metabolism and
the responses to infection or tissue injury. Aldosterone helps to maintain
concentration of solutes (such as sodium) in the extra cellular fluid when
either food intake or metabolic activity.
Adrenal Medulla:
It is under neural control. It contains neurosecretory cells that secrete
epinephrine (adrenaline) control heart rate and carbohydrate metabolism. Brain
centres and hypothalamus govern the secretions via sympathetic nerves.
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